Disclaimer

This packet is for educational purposes only – it is not medical advice. The Psychedelic Safety Institute (PSI) does not condone or endorse illegal activity, but recognizes that psychedelics are used in a variety of settings, including legal grey areas and ‘underground’ settings. Our aim is to help you reduce harm and make informed decisions. Always obey local laws and use your best judgment. New and experienced users alike should remember that no guide can eliminate risk completely.

This packet is for educational purposes only – it is not medical advice. The Psychedelic Safety Institute (PSI) does not condone or endorse illegal activity, but recognizes that psychedelics are used in a variety of settings, including legal grey areas and ‘underground’ settings. Our aim is to help you reduce harm and make informed decisions. Always obey local laws and use your best judgment. New and experienced users alike should remember that no guide can eliminate risk completely.

Written by Andrew Rose

What This Guide Is (and Isn’t)

This packet is a practical harm-reduction guide for people choosing to use psychedelic substances outside of licensed clinical settings. It summarizes best practices drawn from research and real-world experience to maximize safety and minimize risks. It is intended to be useful for both inexperienced and experienced users—we all have more to learn about staying safe.

What this is: It’s a standalone resource covering preparation, risk signs, managing difficulties, dealing with facilitators, and post-trip integration. It draws on PSI’s literature reviews, case reports, and typologies of risks and misconduct to offer evidence-based tips. You’ll also find pointers to substance-specific info and support resources.

What this isn’t: It’s not a substitute for professional medical or psychological care. It doesn’t provide legal advice or encourage any illegal behavior. It won’t guarantee a “safe trip” – psychedelics carry inherent unpredictability. Rather, it gives you tools to reduce the chances of harm and handle challenges if they arise. Use this knowledge responsibly, at your own risk.

Preparation: Set, Setting, Substance, and Support

Careful preparation is essential to set the stage for a safer psychedelic experience. Decades of wisdom boil down to the “Four S’s”: Set, Setting, Substance, and Support. Paying attention to each of these factors can significantly reduce the likelihood of a challenging experience and enhance positive outcomes . Below are key preparation steps:

Mindset (“Set”): Check in with your mental and emotional state before tripping. Are you anxious, depressed, or experiencing turmoil? Psychedelics tend to amplify your current mindset and emotions. It’s best to approach a session when you feel relatively stable, calm, and open. Set a clear intention – know why you are tripping (fun, healing, insight?) – but release expectations about specific outcomes. Realistic expectations help prevent overwhelm or disappointment . If you’re in a fragile state (e.g. grieving or in crisis), reconsider timing; a difficult inner landscape can increase the risk of a distressing trip.

Environment (“Setting”): Choose a safe, comfortable location where you feel secure and won’t be disturbed. This could be a familiar room, a private outdoor spot away from hazards, or another controlled space. Remove or secure any potential dangers (pools, balconies, sharp objects, firearms, etc.). Adjust the sensory environment: have comfortable seating or bedding, gentle lighting, and music if desired. Being too cold, hot, or overstimulated can cause distress, so have blankets, water, and the ability to modulate sound/light. Ensure you won’t have unwanted visitors or obligations; put phones on silent (except a phone for emergencies). A supportive setting helps you relax and navigate the experience more smoothly .

Substance & Dosage: Know what substance and dose you plan to take. Different psychedelics vary widely in effects and risk profiles – LSD lasts 8+ hours and can

sharply alter perception, psilocybin mushrooms often cause nausea, MDMA can raise

body temperature and affect hydration, etc. . Research your substance in advance (e.g. via the Substance-Specific Safety Considerations guide). If possible, test your substance with a reagent kit to confirm its identity and purity. This is especially crucial for powders or tabs sold as LSD, MDMA, etc., as misidentified or adulterated drugs pose serious risks. Start with a moderate or lower dose if you’re not very experienced or it’s a new batch. It’s easier to increase next time than to cope with an overwhelming dose. Measure doses carefully; psychedelics are potent in tiny amounts. Avoid mixing drugs (including alcohol) for your first time with a given psychedelic – poly-substance use can amplify risks and unpredictability. If you’re on any medications or have health conditions, do your homework: for example, antidepressants (SSRIs) can dull classic psychedelic effects and may raise risk of serotonin syndrome if combined with substances like ayahuasca or MDMA. If you have a heart condition, high blood pressure, or a history of seizures, be extremely cautious: psychedelics can cause transient increases in heart rate and blood pressure. When in doubt, consult a medical professional about potential contraindications before tripping.

Support & Consent: Never trip alone if you can help it. Having a sober “trip-sitter” or trusted friend present is one of the best safety measures . Choose someone you trust to look out for you – someone who stays calm under pressure and ideally has some experience with psychedelics. Communicate ahead of time about what help you might want during the trip (for example, “If I get anxious, remind me to breathe”). Agree that your sitter will not leave you alone or let you do dangerous things if you become disoriented. Consent and boundaries are critical: discuss and set clear limits on any physical contact or interventions before you partake. For instance, some people don’t want to be touched while tripping unless absolutely necessary – make your preferences known. Likewise, if you are tripping with friends or in a group, everyone should consent to the plan and understand each other’s boundaries. Remember that intoxication can impair the ability to give true consent, especially to sexual or risky activities – it’s best to avoid any new sexual/intimate situations during the session. Plan all logistics (e.g. whether anyone might drive, who stays where overnight) in advance so no one has to make complex decisions mid-trip.

Trip Planning: Treat a psychedelic journey with the preparation you’d give a trip to remote wilderness. Allocate enough time for the experience and recovery. Plan for the peak and the comedown: for example, LSD or mescaline can last 8-12 hours, so don’t have work or serious duties until the next day. Ensure you have some rest time after – many people feel tired or emotionally tender post-trip. Hydration and snacks: have water and light, easy-to-digest food available (fruits, nuts, etc.), especially for longer sessions or MDMA which can dehydrate you. However, don’t overdo water on MDMA – balance is key to avoid hyponatremia (low sodium). Emergency plan: Hopefully it won’t be needed, but it’s wise to have a plan if things go wrong. This might include having a phone nearby with emergency numbers, a car available (with a sober driver) or knowing your exact location to direct EMTs if needed, and some cash in case you need to taxi to help. If you or someone with you has a prescribed anxiolytic (like a benzodiazepine) and is knowledgeable about its use, you might keep it as a “trip abort” option – but generally avoid taking other substances during a bad trip unless a medical professional advises it. Non-pharmacological calming techniques (discussed below) are usually preferable. Finally, prepare your mindset by learning basic grounding techniques (next section) so you feel equipped to handle anxiety. Thorough preparation—mental, physical, and logistical—significantly lowers the risk of adverse events and helps you feel more confident going in.

(Note: For additional preparation tips and a self-readiness checklist, see BeforeYouTrip.org, which emphasize critical factors like mindset, planning, and knowing your substance.)

Bottom line: Listen to your body and intuition. Mild side effects and emotional swings are normal, but anything that continues to intensify or seems truly abnormal should be taken seriously. It’s always okay to pause and say, “Something doesn’t feel right. ” Early recognition can allow for timely action – whether that’s employing calming techniques, changing the environment, or calling in outside help.

Reducing Risks with Facilitators and Group Experiences

Many people choose to use psychedelics in facilitated settings—maybe an underground guide/therapist, a shamanic ceremony, a retreat circle, or even just a more experienced friend leading the session. While a skilled facilitator or supportive group can enhance safety, there are additional risks to be mindful of whenever others are involved. Power dynamics, trust, and ethics come into play. This section will help you minimize risks associated with facilitators, leaders, or group use, including how to spot and avoid misconduct.

Choose facilitators/guides wisely: In unregulated settings, anyone can call themselves a psychedelic guide or shaman. Their competence and ethics might vary wildly. It’s on you to vet whoever you entrust with your vulnerability. If possible, get referrals from people you trust who have sat with that facilitator. Research their background – do they have training (formal or informal) in harm reduction, therapy, or related fields? How long have they been practicing? A responsible facilitator should screen you (ask about your health, experience, intentions) and be willing to answer your questions too. If a guide promises miraculous cures, guarantees a life-changing outcome, or pressures you to do a higher dose than you’re comfortable with, be cautious. Good facilitators tend to be humble, prioritize safety, and respect your autonomy (for example, they won’t insist you must “break through” at any cost). Trust your gut in initial conversations; if something feels “off” or you feel unduly pressured, it may not be a safe fit. More more on this topic see Fireside’s article by Joshua White and Julliana Mulligan on warning signs when selecting facilitators.

Establish clear boundaries and consent: Before the session, have an explicit discussion about boundaries. This includes physical touch (e.g., is the facilitator ever allowed to touch you, and if so under what circumstances? Many ethical facilitators will only touch you to keep you from harm or as pre-agreed comfort like a hand-hold). Importantly, sexual contact should be completely off-limits in a facilitator/client context. In an altered state, power differentials are amplified and true informed consent is impossible for sexual or romantic interactions. Reputable guides know this and will never initiate or encourage sexual behavior—any that do are behaving unethically. Sadly, instances of sexual misconduct have occurred in underground circles, with practitioners exploiting suggestible clients. Therefore, it’s wise to explicitly say, “No

sexual or romantic interaction will happen during or after the session”, and get their agreement. If you are attending a group ceremony, find out how many facilitators or sitters will be present relative to participants, and what the policy is if someone becomes distressed – do they have a plan and adequate helpers? Consent also applies to things like giving you additional substances (some ceremonies might offer tobacco, cannabis, rapé, etc.). You have the right to decline anything not agreed upon beforehand.

Recognize your vulnerability: Acknowledge that under the influence, you (and others) will be in a highly vulnerable and suggestible state . Facilitators and peers can have outsized influence on your thinking and decisions during and shortly after a psychedelic experience. This is one reason to be careful who you surround yourself with. For example, if a guide starts making strong suggestions (“You should cut ties with your family” or “You need to pay for 5 more sessions to really heal”), you might be unusually open to these ideas while tripping. Healthy facilitation should be supportive, not controlling. You should feel like you’re being cared for, not manipulated. If during a session someone in a position of authority (facilitator or even a dominant group member) starts to coerce or strongly direct your experience in a way you’re not comfortable with, that’s a red flag. This could be emotional coercion (“You have to release your trauma now, do what I say!”) or spiritual exploitation (imposing their belief system on you when you’re suggestible). Be aware of financial exploitation too: some unscrupulous operators might continuously upsell more ceremonies or ask for extravagant donations especially when you’re euphoric or raw.

During the session stay aware (as much as you can): Once you’re actually in the journey, it can be hard to advocate for yourself, which is why pre-trip agreements are key. However, if you do notice something inappropriate – for instance, your facilitator is breaking a boundary (like touching you in a way that wasn’t agreed to, or sharing your private revelations with the group without consent), try to speak up or remove yourself from the situation if possible. If you are in a group and feel uncomfortable, seek out a sober ally or simply state, “I need a break” and move away for a bit. It might help to have a trusted friend present in a facilitator-run session (even if they’re not tripping) to act as your advocate if needed. Some underground therapy arrangements allow a friend or partner to be there – consider that added protection if you have any doubts. Remember, no legitimate guide will ever be offended by you prioritizing your safety.

If they react defensively or dismissively to safety concerns (“Don’t worry about that, just trust me completely”), that’s a warning sign of a potentially unsafe dynamic.

After the session – reflect and report: After the effects wear off, take note of how the facilitator behaved. Positive sign: they respect your boundaries, help you integrate without making you dependent on them, and behave professionally. Negative sign: you feel violated, or they cross boundaries then or in follow-up (e.g. an unwanted sexual advance “after” the session, which is still not okay). If serious misconduct occurred, reach out for support – you do not have to just accept it. There may be community groups (like the **PSI or others like the Sanctuary for Independent Neural Exploration (SHINE) who compiled case reports) where you can confidentially report bad actors to warn others. Practitioner misconduct can cause real trauma, and you deserve support if it happens. Know that egregious harms like sexual abuse or other clear exploitation are unequivocally unethical and often illegal. More subtle forms (psychological manipulation, blurred boundaries) are also harmful . If you have a therapist or unbiased person to talk to, debrief with them to get an outside perspective.

Misconduct warning signs: Based on PSI’s Misconduct Typology, here are some concrete red flags to watch for with facilitators or group leaders:

Sexual or romantic suggestions: As stressed, any hint of this is a deal-breaker. This includes the facilitator commenting on your body or attractiveness, suggesting “sexual energy” is part of the healing, or initiating any physical intimacy. Ethical guides keep strict platonic boundaries – even if you think you want a romantic connection during the session, a good facilitator will never reciprocate in that context.

Authority abuse: If the person uses their position to control you in ways not related to safety – e.g., making you run errands, pressuring you into non-consensual activities (like saying you must participate in a heavy emotional catharsis exercise that you’re uncomfortable with), or using knowledge of your psyche to manipulate you later.

Lack of transparency: E.g., they won’t tell you what substance or dose you’re being given (“It’s a secret ceremony medicine”). You have a right to know what you ingest.

Neglect or incompetence: If during the session the facilitator becomes unavailable (physically leaves, falls asleep, or is too intoxicated themselves), that’s dangerous. If a co-facilitator or participant is freaking out and the leader has no plan or skill to help, that shows poor training.

Financial exploitation: Examples: unexpectedly demanding more money mid-session or afterward, asking you to invest in their ventures, or significantly upping fees later using your emotional attachment/vulnerability.

Cult-like vibes: Grandiose claims like “Only I can guide you to true awakening” or discouraging you from seeing other professionals (therapists, doctors). If they attempt to isolate you or make you dependent on the group or on them for validation, be very cautious.

Reducing risk in group settings: If you attend a psychedelic group ceremony (like an ayahuasca circle or psilocybin retreat), beyond vetting the leaders, also consider the group composition and setting. Are there enough facilitators or sitters for the number of participants? Is there gender balance among facilitators (some feel safer if at least one facilitator shares their gender or there are checks and balances)? Does the group provide a pre-talk about safety (e.g., instructing everyone to respect each other’s space, not to interfere with others’ processes)? In a good group, participants generally do not physically interact much during the actual sessions unless you know each other and it’s consensual – everyone should be focused on their own journey. Beware of any scenario where group members are encouraged to touch or interact in an altered state without prior agreement.

By being picky about who you work with, setting clear boundaries, and staying aware, you can hugely reduce the risk of misconduct or harm in facilitated and group psychedelic experiences. The vast majority of underground facilitators truly want to help and will behave ethically – but it only takes one bad actor to cause serious damage, so it’s worth being proactively cautious. Remember that your safety and well being come first. If something doesn’t feel right, you have every right to say no, to leave, or to not partake.

(For more detailed discussion of practitioner misconduct and ethics, see PSI’s Misconduct Typology document, which outlines scenarios of both egregious abuse and subtle ethical violations.)

Risks During the Experience: When Things Feel Intense

Psychedelic experiences can bring up waves of feeling that are powerful, unfamiliar, or even frightening. If you find yourself in a difficult moment, the most important thing to remember is that these experiences are rarely dangerous in themselves. Substances like psilocybin, LSD, or ayahuasca are generally safe for the body. What feels overwhelming is usually the intensity of the mind and emotions — and this will pass.

When the storm builds, start with your breath. Slow, steady breathing is one of the simplest anchors you have: inhale deeply, then let the exhale be even longer than the inhale. This signals your nervous system that it’s safe to settle. You don’t need to “fix” what’s happening; you only need to breathe with it.

Next, pay attention to your body. Sometimes the body needs to move to release what the mind is holding. Stretch your arms wide, shake out your hands, even try a yoga pose or two — whether you know what you’re doing or not, the act of moving shifts energy. Humming, chanting, or simply making sounds can have a surprising effect: you’ll feel the vibration in your chest, throat, and skull, and this sensation alone can help emotions shift and move through you.

If sitting still feels right, that’s okay too. Curl up under a blanket, or splash cool water on your face. Sip some water slowly. If you’re too stimulated, close your eyes and let the music guide you; if you’re trapped in your head, open your eyes and notice something simple in the room — a color, a texture, a light. Small changes in the environment can feel like a reset button.

Through it all, remind yourself: “This is the psychedelic. This is temporary. I will come through this. ”Even when thoughts feel dire — “I’m stuck,” “I can’t go on” — remember they are part of the experience, not the whole truth. Approaching with curiosity rather than resistance can help: “What is this showing me?”

Finally, know that you don’t have to do it all alone. Ideally, a sober and supportive friend is nearby. If you’re on your own, you can still reach out. The Fireside Project support line (+1-62-FIRESIDE) is there for exactly these moments; trained volunteers can talk with you until you feel steadier. A trusted friend on the phone can be just as grounding.

Most challenging moments don’t require emergency action — they need time, patience, and gentleness. By breathing, moving, making sound, and remembering you are safe, you give yourself the best chance to ride the wave until it calms.

Of course, emergencies do happen. While it might be challenging while under the effects of a psychedelic to differentiate between real medical warning signs and intense aspects of the experience (one reason it’s good to have someone close by monitoring safety), do not hesitate to escalate to calling 911 if you are concerned about chest pain, irregular heart beat, or breathing troubles.

After the Trip: Integration and Ongoing Safety Monitoring

The psychedelic journey doesn’t end when the acute effects wear off. In fact, what happens in the days and weeks after can be just as important for long-term well-being. This phase is often called “integration”, meaning the process of making sense of the experience and weaving any insights or lessons into your daily life. Good integration can maximize positive outcomes and help prevent lingering harms. Additionally, it’s crucial to monitor for any negative after-effects or emerging risks post-use. This section covers how to take care of yourself (or your friend) after the trip, and how to notice if something isn’t right.

Give yourself time to recover: Psychedelic experiences – whether beautiful or challenging – can be mentally and physically draining. It’s normal to feel fatigued or emotionally “raw” the next day. Plan for some self-care: stay hydrated, eat nourishing food, and get a good night’s sleep. Gentle activities like a walk in nature, stretching, or a warm bath can help you recenter. Avoid heavy stressors or major decisions for at least a day or two. Emotionally, you might feel a lingering afterglow of joy or peace, or conversely you might feel a bit low or anxious (sometimes called the “post-trip blues”). These swings often even out after a short period. However, if you had a very intense experience, it could take days or weeks to fully process. Be patient with yourself – it’s okay if you feel “off” or more emotional than usual for a little while.

Reflect and make meaning: Sometime soon after the journey (within a day or two), find a way to reflect on what happened. Many find it helpful to journal – write down what you remember, significant feelings, visions, or thoughts. Don’t worry if it’s incoherent; the act of writing helps externalize the experience. You can also draw, play music, or use any creative expression to represent what you went through. If you had specific insights (“I realized I need to forgive my sister” or “I saw how my ego is holding me back”), write those down too. Not every insight will necessarily be profound or even make sense later – that’s okay. The goal is to capture the experience while it’s fresh. Over time, you can revisit these notes and see what still resonates.

Talk it through: Psychedelics are often described as “ineffable” (hard to put into words), but discussing your experience with a trusted person can greatly aid integration. This could be a friend who understands psychedelics, a therapist (some specialize in psychedelic integration), or an integration circle (group meetings where people share and support each other’s post-trip processing). When you talk about it, you “digest” the experience – even just describing the tough parts can reduce their emotional charge. If something confusing or frightening happened during the trip, getting an outside perspective can help you reframe it. For example, you might say, “I felt like I died and it really scared me,” and a friend or therapist could help you explore

that (was it possibly a symbolic ego-death rather than literal?). Meaning-making is a key part of integration: try to glean if there are any lessons or actionable insights to carry forward. Maybe the experience highlighted unhealthy patterns you want to change, or gave you a new appreciation for life. Supportive others can assist in translating those insights into practical steps. Research shows that having adequate integration support – through therapy or community – helps individuals process and apply their psychedelic experiences in positive ways.

Apply insights gradually: It’s common to come out of a psychedelic experience feeling like you’ve “figured out” big life changes you need to make (ending a toxic relationship, quitting a job, etc.). Some of these realizations may be very valuable – but be cautious of making sudden drastic changes immediately after a trip. Your perceptions might be a bit over-optimistic or skewed in the immediate afterglow (or conversely, if the trip was dark, you might feel overly pessimistic). Give it a few days and re-evaluate those big decisions with a clear mind. That said, do try to implement positive changes in your life, step by step. If you realized you need to take better care of your health, start with small steps like improved diet or exercise. If you had a spiritual epiphany, integrate it by maybe starting a meditation or prayer routine. The key is turning insights into real changes in a sustainable way . Sometimes people feel frustrated when a profound insight “fades” after a while – writing down and consciously working on it can prevent it from slipping away. Set realistic goals inspired by your experience and maybe enlist a friend or therapist to help keep you accountable.

Monitor for persisting issues: While most people return to baseline after a psychedelic within a day or so, stay attentive to your mental and physical health in the weeks following. A small minority of users experience longer-lasting adverse effects. For example, Hallucinogen Persisting Perception Disorder (HPPD) involves lingering visual disturbances (tracers, flickering lights) or perceptual changes well after the drug has left the body. This is rare (some estimates<1% of users) and often fades with time, but if you notice persistent visuals or dissociation that doesn’t resolve in a week or two, consult a healthcare professional . Another thing to watch is mood and anxiety: if you find yourself stuck in a depressive or anxious spell in the aftermath, or having flashbacks to difficult parts of the trip, don’t ignore it. Psychedelics can bring up latent

psychological content – for some, this leads to improvements, but for others it might trigger unresolved issues like trauma or anxiety that need further attention. If a trip seems to have unsettled you in an ongoing way (e.g. new panic attacks, trouble sleeping due to nightmares, or feeling “detached” from reality/derealization), that’s a sign to seek professional help. Therapists, especially those familiar with trauma or psychedelic integration, can help you work through these effects. Persistent problems are not common, but they can happen even from a single use, so it’s wise to do a self-check: “How am I feeling in the weeks after? Any concerning changes in my thinking or functioning?” Have friends or family you trust also give feedback – sometimes others notice changes (like unusual paranoia or mood swings) that you might not.

Avoid immediate re-use: After a powerful experience, some people are tempted to use psychedelics again very soon – either to chase another high or to “fix” something that felt unresolved. Generally, it’s best to give yourself ample time (weeks to months) before the next journey. Frequent high-dose use can lead to diminishing returns and potentially increase risks like psychological dependency or difficulty integrating . Each trip should ideally be integrated before the next is taken on. However, if you had a notably traumatic experience, sometimes a carefully managed follow-up session in a safer setting with better support can help you work through it – but this should be approached cautiously, ideally with professional guidance. Don’t rush back in just because you didn’t like what you saw; give it time, gather support, and decide with a clear head if and when to use again.

Harm reduction never stops: Even post-trip, keep practicing harm reduction. This might mean continuing psychotherapy or self-work that the psychedelic experience initiated. For example, if a journey revealed parts of yourself that need healing, integration could involve continuing that work sober (therapy, support groups, meditation, etc.). Also, pay attention to any signs of developing a pattern of overuse. Psychedelics are not chemically addictive, but one can become psychologically reliant on the profound experiences or community. If you notice you’re planning another session very frequently or feeling like you need a psychedelic to cope, step back and evaluate. It’s important to re-emphasize balance – these substances can be transformative tools, but they aren’t a panacea or a replacement for other forms of growth.

In summary, integration is about caring for yourself and learning from the experience. Many experts consider integration the most crucial phase for deriving lasting benefit . Use the insights as an opportunity for positive change, but also keep an eye out for any negative fallout so you can address it promptly. With proper integration, even a challenging trip can become a source of growth, and any lingering issues can be managed with the right support.

(Need specific tips for each substance’s after-effects or risks? See the Substance-Specific Safety Considerations resource, which covers post-use effects like MDMA “crash,” ketamine bladder concerns, etc.)

Substance-Specific Considerations

Every psychedelic is different. This guide has focused on general principles, but it’s important to know the particular safety considerations of the specific substance you plan to use. LSD, psilocybin, MDMA, DMT, mescaline, 5-MeO-DMT, ketamine, etc., each have unique effect profiles, durations, and risk factors. Dose thresholds, onset times, and potential adverse effects vary widely. For example, MDMA can risk dehydration or overheating, whereas 5-MeO-DMT can come on extremely fast and intense, requiring a very controlled setting. Some substances (like ayahuasca or ibogaine) have dietary and medication contraindications due to MAOI content, whereas others (like LSD) mainly require attention to duration and dose. Poly-drug combinations also drastically alter safety (for instance, combining MDMA with LSD – “candyflipping” – can be more taxing than either alone). As one public health campaign puts it: “What substance am I taking? That’s critical – different substances have different risk-benefit profiles from MDMA to LSD to psilocybin. They’re really different.”.

Refer to the Substance-Specific Safety Considerations packet for detailed guidance on individual psychedelics. That resource provides tailored tips on safe dosing ranges, what to expect, and particular dangers to watch for with each drug. For instance, it covers why you shouldn’t combine ayahuasca with SSRIs, how to test MDMA or LSD for adulterants, and which psychedelics are more likely to cause certain long-term issues. When preparing for a journey, use that packet alongside this general guide. Knowledge of the substance is a core part of preparation – it can be literally life-saving (for example, recognizing an Nbome (fake LSD) by testing can prevent a potential overdose situation).

In short: do your homework on the specific psychedelic. A little targeted research goes a long way to prevent harm. Each compound has its own “personality” and safety profile – respect those differences as you plan for a safe experience.

Crisis and Support Resources

Despite best efforts, emergencies or crises can occur. It’s important to know there are resources out there, you’re not alone in this. Below is a list of key support options for psychedelic-related crises or integration help. Consider saving these contacts in your phone or writing them down before a session, just in case.

Fireside Project Psychedelic Peer Support Line (USA)

A free, confidential support line specifically for people having psychedelic experiences (or processing past ones). Call or text 623-473-7433, 11:00 am – 11:00 pm Pacific Time, 7 days a week . Trained volunteers (who understand psychedelics) will talk you through a challenging trip, ground you, or help you integrate afterward. They support callers in any stage of a journey with compassion and non-judgment. This line is like having a “sitter” available by phone – don’t hesitate to use it if you need someone to stay present with you in a hard moment. It’s totally free and anonymous.

The Zendo Project (Harm Reduction for Events)

Zendo is an organization that provides onsite psychedelic peer support at festivals and events, and also offers education on how to handle difficult psychedelic experiences. If you’re at a large festival or gathering and someone is freaking out, look for the Zendo or medical tent – often events will have a space where trained volunteers implement principles like “talking someone through, not down” in a calm environment . Zendo’s approach has helped de-escalate countless bad trips. Even if you’re not at an event, their website has resources and guides for sitters that can be useful for anyone. (Website: zendoproject.org)

Challenging Psychedelic Experiences Project

Provides resources and peer group support for processing especially difficult trip experiences.

Global Psychedelic Society

An international hub connecting individuals to local integration circles and peer communities.

Medical Emergency Services (911 or local emergency number)

If a situation becomes physically dangerous or unmanageable – e.g., someone is non-responsive, having a seizure or serious injury, or poses an immediate threat to themselves/others – call emergency services immediately. Paramedics and ER staff are trained to handle drug-related crises. Yes, legal issues can be a worry, but most emergency responders prioritize health over punishment. Be honest with medical personnel about what was taken; this helps them provide the right treatment. In many places, Good Samaritan laws protect those who seek help in overdose or emergency situations (for example, in some U.S. states you won’t be prosecuted for drug possession if you call 911 for an overdose). Even without such laws, the risk of not getting help is far greater than the legal risk if someone’s life is at stake. When calling, stay calm and give clear details (substance used, symptoms, location). If you are the one in trouble and able to call, don’t delay out of fear – your life is more important than any legal consequences.

Psychological Crisis Hotlines

If a psychedelic experience triggers ongoing mental health crisis (such as suicidal thoughts, severe anxiety, or PTSD symptoms in the aftermath), you can reach out to general crisis lines. In the U.S., 988 is the Suicide & Crisis Lifeline (24/7 free support from trained counselors). They won’t necessarily know about psychedelics specifically, but they know how to handle panic, suicidal ideation, and can help you stay safe in the moment. Sometimes just voicing what you’re feeling to a compassionate stranger can prevent self-harm. If you prefer text, in the U.S. you can text HOME to 741-741 (Crisis Text Line). Internationally, find your country’s equivalent crisis line or use services like Samaritans (UK), etc. Don’t be afraid to use these resources if you need to – a difficult trip can stir up real mental health struggles, and help is available.

Psychedelic Integration Therapists / Groups

For longer-term integration or support, consider seeking out a therapist who is knowledgeable about psychedelics. They won’t judge you for using an illegal substance; their role is to help you process it. Integration groups (sometimes offered by psychedelic societies or holistic centers) allow you to share your experience in a safe, confidential space with others who’ve had similar journeys. This can be immensely validating and healing, especially if your trip was confusing or challenging. The following organizations have directories where you can source this kind of support:

Psychedelic.Support

Online directory for finding integration therapists and participating in free virtual circles.

Fluence

An education company focused on training psychedelic therapists, with a directory of licensed clinicians trained in psychedelic-informed mental health care.

Nectara

A platform offering education, group programs, and a directory of guides for translating psychedelic insights into life changes.

Online Communities (with caution)

Online forums like the r/Psychedelics, r/TripSitter or Bluelight have many experienced users who give advice. Erowid’s “Bad Trip” reports can also remind you that others have gotten through similar struggles. However, use caution online—advice quality varies and your mileage may vary. Never accept medical advice solely from anonymous internet folks if it’s a serious issue. Use professionals for that. But for moral support or shared stories, online communities can be helpful.

Conclusion

Psychedelics can be powerful and unpredictable. Most of the time they are physically safe, but they can still put people at risk if the environment isn’t right, if difficult feelings become overwhelming, or if medical concerns go unnoticed. This guide has shared ways to prepare, take care of yourself during the experience, and know what to do if things get hard. Remember: most difficult moments are not dangerous, and they pass.


No single guide can remove all risks, but being informed gives you choices. You’re part of a growing community that values safety, respect, and shared learning. Talk about what you learn, listen to others’ stories, and keep expanding your toolkit.

Disclaimer

Disclaimer

Disclaimer

These materials have limitations. Some analysis was AI-assisted and may contain errors. Literature reviews were based on nearly a thousand accessible papers, though not all relevant publications could be included. These resources are intended for educational purposes to inform the psychedelic community.

These materials have limitations. Some analysis was AI-assisted and may contain errors. Literature reviews were based on nearly a thousand accessible papers, though not all relevant publications could be included. These resources are intended for educational purposes to inform the psychedelic community. Always consult qualified healthcare providers for medical concerns and follow local laws. While these materials aim to support safer experiences,  psychedelic experiences carry inherent unpredictability that cannot be fully eliminated.

Always consult qualified healthcare providers for medical concerns and follow local laws. While these materials aim to support safer experiences,  psychedelic experiences carry inherent unpredictability that cannot be fully eliminated.

Use and Attribution

For guidelines on referencing, sharing, using, and building upon the materials developed by the Psychedelic Safety Institute (PSI), click here.

Let’s build the future together

Your ideas and experiences drive this field forward. Share your thoughts, ask a question, or suggest a collaboration — we’re always open to new connections.

Or reach us directly

hello@psychedelicsafety.institute

Let’s build the future together

Your ideas and experiences drive this field forward. Share your thoughts, ask a question, or suggest a collaboration — we’re always open to new connections.

Or reach us directly

hello@psychedelicsafety.institute

Let’s build the future together

Your ideas and experiences drive this field forward. Share your thoughts, ask a question, or suggest a collaboration — we’re always open to new connections.

Or reach us directly

hello@psychedelicsafety.institute

Let’s build the future together

Your ideas and experiences drive this field forward. Share your thoughts, ask a question, or suggest a collaboration — we’re always open to new connections.

Or reach us directly

hello@psychedelicsafety.institute

Stay Connected

Join our community of researchers, practitioners, policymakers, advocates, and harm reductionists working to align the psychedelic field around safety and public interest.

Stay Connected

Join our community of researchers, practitioners, policymakers, advocates, and harm reductionists working to align the psychedelic field around safety and public interest.

Stay Connected

Join our community of researchers, practitioners, policymakers, advocates, and harm reductionists working to align the psychedelic field around safety and public interest.

Stay Connected

Join our community of researchers, practitioners, policymakers, advocates, and harm reductionists working to align the psychedelic field around safety and public interest.